Palbociclib in Combination With Fulvestrant in Women With Hormone Receptor-Positive/HER2-Negative Advanced Metastatic Breast Cancer: Detailed Safety Analysis From a Multicenter, Randomized, Placebo-Controlled, Phase III Study (PALOMA-3).

@article{Verma2016PalbociclibIC,
  title={Palbociclib in Combination With Fulvestrant in Women With Hormone Receptor-Positive/HER2-Negative Advanced Metastatic Breast Cancer: Detailed Safety Analysis From a Multicenter, Randomized, Placebo-Controlled, Phase III Study (PALOMA-3).},
  author={Sunil Verma and Cynthia Huang Bartlett and Patrick Schnell and Angela DeMichele and Sherene Loi and Jungsil Ro and Marco Colleoni and Hiroji Iwata and N. Harbeck and Massimo Cristofanilli and Ke Zhang and Alexandra Thiele and Nicholas C. Turner and Hope S Rugo},
  journal={The oncologist},
  year={2016},
  volume={21 10},
  pages={1165-1175}
}
BACKGROUND Palbociclib enhances endocrine therapy and improves clinical outcomes in hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC). Because this is a new target, it is clinically important to understand palbociclib's safety profile to effectively manage toxicity and optimize clinical benefit. MATERIALS AND METHODS Patients with endocrine-resistant, HR-positive/HER2-negative MBC (n = 521) were randomly assigned 2:1 to… CONTINUE READING

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