Palbociclib (PD 0332991): targeting the cell cycle machinery in breast cancer

@article{Rocca2014Palbociclib0,
  title={Palbociclib (PD 0332991): targeting the cell cycle machinery in breast cancer},
  author={Andrea Rocca and Alberto Farolfi and Sara Bravaccini and Alessio Schirone and Dino Amadori},
  journal={Expert Opinion on Pharmacotherapy},
  year={2014},
  volume={15},
  pages={407 - 420}
}
INTRODUCTION The cyclin D-cyclin-dependent kinases 4 and 6 (CDK4/6)-retinoblastoma (Rb) pathway, governing the cell cycle restriction point, is frequently altered in breast cancer and is a potentially relevant target for anticancer therapy. [] Key Method A literature search on the topic was conducted through PubMed and the proceedings of the main cancer congresses of recent years. EXPERT OPINION The combination of palbociclib with endocrine agents is a very promising treatment and Phase III clinical trials…

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