Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms.


Pak kinases are thought to play critical roles in cell migration and invasion. Here, we analyze the roles of Pak1 and Pak2 in breast carcinoma cell invasion using the transient transfection of small interfering RNA. We find that although both Pak1 and Pak2 contribute to breast carcinoma invasion stimulated by heregulin, these roles are mediated by distinct… (More)
DOI: 10.1128/MCB.01532-07