Pairwise network mechanisms in the host signaling response to coxsackievirus B3 infection.

@article{Garmaroudi2010PairwiseNM,
  title={Pairwise network mechanisms in the host signaling response to coxsackievirus B3 infection.},
  author={Farshid S. Garmaroudi and D. Marchant and Xiaoning Si and Abbas Khalili and Ali Bashashati and Brian W Wong and Aline Tabet and Raymond T. Ng and Kevin Murphy and Honglin Luo and Kevin A. Janes and Bruce McManus},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 39},
  pages={17053-8}
}
Signal transduction networks can be perturbed biochemically, genetically, and pharmacologically to unravel their functions. But at the systems level, it is not clear how such perturbations are best implemented to extract molecular mechanisms that underlie network function. Here, we combined pairwise perturbations with multiparameter phosphorylation… CONTINUE READING