Pairwise detection of site-specific receptor phosphorylations using single-molecule blotting

@inproceedings{Kim2016PairwiseDO,
  title={Pairwise detection of site-specific receptor phosphorylations using single-molecule blotting},
  author={Kyung Lock Kim and Daehyung Kim and Seongsil Lee and S G Kim and Jung Eun Noh and Joung-Hun Kim and Young Chan Chae and Jong-Bong Lee and Sung Ho Ryu},
  booktitle={Nature communications},
  year={2016}
}
Post-translational modifications (PTMs) of receptor tyrosine kinases (RTKs) at the plasma membrane (PM) determine the signal transduction efficacy alone and in combination. However, current approaches to identify PTMs provide ensemble results, inherently overlooking combinatorial PTMs in a single polypeptide molecule. Here, we describe a single-molecule… CONTINUE READING