Pairing of Vbeta6 with certain Valpha2 family members prevents T cell deletion by Mtv-7 superantigen.

@article{AudeGarcia2000PairingOV,
  title={Pairing of Vbeta6 with certain Valpha2 family members prevents T cell deletion by Mtv-7 superantigen.},
  author={Catherine Aude-Garcia and Antoine Attinger and Dominique Housset and H Robson Macdonald and Hans Acha-Orbea and Patrice N Marche and Evelyne Jouvin-Marche},
  journal={Molecular immunology},
  year={2000},
  volume={37 16},
  pages={1005-12}
}
Superantigens (SAg) are proteins of bacterial or viral origin able to activate T cells by forming a trimolecular complex with both MHC class II molecules and the T cell receptor (TCR), leading to clonal deletion of reactive T cells in the thymus. SAg interact with the TCR through the beta chain variable region (Vbeta), but the TCR alpha chain has been shown… CONTINUE READING