Pairing computation with experimentation: a powerful coupling for understanding T cell signalling

@article{Chakraborty2010PairingCW,
  title={Pairing computation with experimentation: a powerful coupling for understanding T cell signalling},
  author={Arup K. Chakraborty and Jayajit Das},
  journal={Nature Reviews Immunology},
  year={2010},
  volume={10},
  pages={59-71}
}
T cells are activated when extracellular stimuli, such as a ligand binding to the T cell receptor, are converted into functional outputs by the T cell signalling network. T cell receptor signalling is a highly complex, stochastic and dynamic process involving many interacting proteins. This complexity often confounds intuition, making it difficult to develop mechanistic principles that underly experimental observations. In this Review, we describe how computational approaches can partner… CONTINUE READING

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