Paired-pulse depression of unitary quantal amplitude at single hippocampal synapses.

  title={Paired-pulse depression of unitary quantal amplitude at single hippocampal synapses.},
  author={Gong Chen and N Charles Harata and Richard W. Tsien},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 4},
At central synapses, quantal size is generally regarded as fluctuating around a fixed mean with little change during short-term synaptic plasticity. We evoked quantal release by brief electric stimulation at single synapses visualized with FM 1-43 dye in hippocampal cultures. The majority of quantal events evoked at single synapses were monovesicular, based on examination of amplitude distribution of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-receptor-mediated responses… CONTINUE READING

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