Paired multiplex reverse-transcriptase polymerase chain reaction (PMRT-PCR) analysis as a rapid and accurate diagnostic tool for the detection of MLL fusion genes in hematologic malignancies

@article{Andersson2001PairedMR,
  title={Paired multiplex reverse-transcriptase polymerase chain reaction (PMRT-PCR) analysis as a rapid and accurate diagnostic tool for the detection of MLL fusion genes in hematologic malignancies},
  author={Anna Erika Elisabeth Andersson and Martin H{\"o}glund and Bertil Johansson and Carin Lassen and Rolf Billstr{\"o}m and Stanislaw Garwicz and P. G. Nilsson and Felix Mitelman and Thoas Fioretos},
  journal={Leukemia},
  year={2001},
  volume={15},
  pages={1293-1300}
}
The MLL gene in chromosome band 11q23 is frequently rearranged in acute lymphoblastic and acute myeloid leukemias. To date, more than 50 different chromosomal regions are known to participate in translocations involving 11q23, many of which affect MLL. The pathogenetically important outcome of these rearrangements is most likely the creation of a fusion gene consisting of the 5′ part of the MLL gene and the 3′ end of the partner gene. Although abnormalities of the MLL gene as such are generally… CONTINUE READING