Paired helical filaments and the cytoplasmic-nuclear interface in Alzheimer's disease.

@article{Metuzals1988PairedHF,
  title={Paired helical filaments and the cytoplasmic-nuclear interface in Alzheimer's disease.},
  author={J. Metuzals and Yves O Robitaille and Stephen Houghton and Serge Gauthier and Ren{\'e}e Leblanc},
  journal={Journal of neurocytology},
  year={1988},
  volume={17 6},
  pages={827-33}
}
The cytoplasmic-nuclear interface has been investigated by conventional thin sectioning electron microscopy of neurons from frontal lobe biopsies of 13 patients with Alzheimer's disease. Nine patients were in the early and intermediate stages of the disease and four patients in the advanced stage. Fascicles of paired helical filament-like strands and paired… CONTINUE READING