Paired acute inhalation test reveals that acetaldehyde toxicity is higher in aldehyde dehydrogenase 2 knockout mice than in wild-type mice.

Abstract

Aldehyde dehydrogenase 2 (ALDH2) is an important enzyme that oxidizes acetaldehyde. Approximately 45% of Chinese and Japanese individuals have the inactive ALDH2 genotypes (ALDH2*2/*2 and ALDH2*1/*2); acute inhalation toxicity of acetaldehyde has not been evaluated in these populations. We compared the toxicity between wild-type (Aldh2+/+) and Aldh2… (More)

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Cite this paper

@article{Isse2005PairedAI, title={Paired acute inhalation test reveals that acetaldehyde toxicity is higher in aldehyde dehydrogenase 2 knockout mice than in wild-type mice.}, author={Toyohi Isse and Tsunehiro Oyama and Koji Matsuno and Masanori Ogawa and Rie Narai-Suzuki and Tetsunosuke Yamaguchi and Tomoe Murakami and Tsuyoshi Kinaga and Iwao Uchiyama and Toshihiro Kawamoto}, journal={The Journal of toxicological sciences}, year={2005}, volume={30 4}, pages={329-37} }