Painted turtle cortex is resistant to an in vitro mimic of the ischemic mammalian penumbra.

@article{Pamenter2012PaintedTC,
  title={Painted turtle cortex is resistant to an in vitro mimic of the ischemic mammalian penumbra.},
  author={Matthew E Pamenter and David W. Hogg and Xiang Qun Gu and Leslie T Buck and Gabriel G. Haddad},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2012},
  volume={32 11},
  pages={2033-43}
}
Anoxia or ischemia causes hyperexcitability and cell death in mammalian neurons. Conversely, in painted turtle brain anoxia increases γ-amino butyric acid (GABA)ergic suppression of spontaneous electrical activity, and cell death is prevented. To examine ischemia tolerance in turtle neurons, we treated cortical sheets with an in vitro mimic of the penumbral region of stroke-afflicted mammalian brain (ischemic solution, IS). We found that during IS perfusion, neuronal membrane potential (V(m… CONTINUE READING