Painful tonic heat stimulation induces GABA accumulation in the prefrontal cortex in man.

@article{Kupers2009PainfulTH,
  title={Painful tonic heat stimulation induces GABA accumulation in the prefrontal cortex in man.},
  author={Ron Kupers and Else Rub{\ae}k Danielsen and Henrik Kehlet and Rune Christensen and Carsten Thomsen},
  journal={Pain},
  year={2009},
  volume={142 1-2},
  pages={89-93}
}
Relatively little is known on pain-induced neurotransmitter release in the human cerebral cortex. We used proton magnetic resonance spectroscopy (1H-MRS) during tonic painful heat stimulation to test the hypothesis of increases in both glutamate and GABA, two neurotransmitters with a key role in pain processing. Using a 3T MR scanner, we acquired spectra from the rostral anterior cingulate cortex (rACC) in 13 healthy right-handed subjects at rest and during painful heat stimulation. The painful… CONTINUE READING
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