Painful neuropathy decreases membrane calcium current in mammalian primary afferent neurons

@article{Hogan2000PainfulND,
  title={Painful neuropathy decreases membrane calcium current in mammalian primary afferent neurons},
  author={Quinn H. Hogan and J E Mccallum and Constantine D Sarantopoulos and Mark Aason and Zeljko J Bosnjak},
  journal={Pain},
  year={2000},
  volume={86},
  pages={43-53}
}
Hyperexcitability of the primary afferent neuron leads to neuropathic pain following injury to peripheral axons. Changes in calcium channel function of sensory neurons following injury have not been directly examined at the channel level, even though calcium is a primary second messenger-regulating neuronal function. We compared calcium currents (I(Ca)) in 101 acutely isolated dorsal root ganglion neurons from 31 rats with neuropathic pain following chronic constriction injury (CCI) of the… CONTINUE READING

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