Pain perception is altered by a nucleotide polymorphism in SCN9A.


The gene SCN9A is responsible for three human pain disorders. Nonsense mutations cause a complete absence of pain, whereas activating mutations cause severe episodic pain in paroxysmal extreme pain disorder and primary erythermalgia. This led us to investigate whether single nucleotide polymorphisms (SNPs) in SCN9A were associated with differing pain… (More)
DOI: 10.1073/pnas.0913181107


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@article{Reimann2010PainPI, title={Pain perception is altered by a nucleotide polymorphism in SCN9A.}, author={F Reimann and James J. Cox and Inna Belfer and Luda Diatchenko and Dmitri V. Zaykin and Duncan McHale and Joost P. H. Drenth and Feng Dai and Jerry Wheeler and Frances A. Sanders and Linda S Wood and Tian-Xia Wu and Jaro Karppinen and Lone Nikolajsen and Minna M{\"a}nnikk{\"{o} and Mitchell B. Max and Carly Kiselycznyk and Minakshi Poddar and Ren{\'e} H. M. te Morsche and Shad B. Smith and Dustin G. Gibson and Anthi Kelempisioti and William O Maixner and F M Gribble and C Geoffrey Woods}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2010}, volume={107 11}, pages={5148-53} }