Pain perception in knees with circumscribed cartilage lesions is associated with intra-articular IGF-1 expression.

@article{Schmal2011PainPI,
  title={Pain perception in knees with circumscribed cartilage lesions is associated with intra-articular IGF-1 expression.},
  author={Hagen Schmal and Philipp Niemeyer and Norbert P Suedkamp and Ulrike V. Gerlach and David Dovi-Akue and Alexander T. Mehlhorn},
  journal={The American journal of sports medicine},
  year={2011},
  volume={39 9},
  pages={1989-96}
}
BACKGROUND Circumscribed cartilage defects are considered as prearthritic lesions and lead to differential intra-articular cytokine expression. Mechanisms of associated pain development and influence of smoking behavior are not yet fully understood in humans. PURPOSE This study aimed to reveal relations between synovial cytokine levels in knees with circumscribed cartilage defects and pain sensation. STUDY DESIGN Descriptive laboratory study. METHODS In a clinical trial, knee lavage… CONTINUE READING