Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons.

@article{Isensee2014PainMR,
  title={Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons.},
  author={Joerg Isensee and Mandy Diskar and Steffen Waldherr and Ren{\'e} Buschow and Jan Hasenauer and Anke Prinz and Frank Allg{\"o}wer and Friedrich W Herberg and Tim Hucho},
  journal={Journal of cell science},
  year={2014},
  volume={127 Pt 1},
  pages={216-29}
}
Knowledge about the molecular structure of protein kinase A (PKA) isoforms is substantial. In contrast, the dynamics of PKA isoform activity in living primary cells has not been investigated in detail. Using a high content screening microscopy approach, we identified the RIIβ subunit of PKA-II to be predominantly expressed in a subgroup of sensory neurons. The RIIβ-positive subgroup included most neurons expressing nociceptive markers (TRPV1, NaV1.8, CGRP, IB4) and responded to pain-eliciting… CONTINUE READING