Pain modulation by release of the endogenous cannabinoid anandamide.

  title={Pain modulation by release of the endogenous cannabinoid anandamide.},
  author={Jennifer M. Walker and Susan M Huang and Nicole Strangman and K. L. Tsou and M C Sa{\~n}udo-Pe{\~n}a},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 21},
Synthetic cannabinoids produce behavioral analgesia and suppress pain neurotransmission, raising the possibility that endogenous cannabinoids serve naturally to modulate pain. Here, the development of a sensitive method for measuring cannabinoids by atmospheric pressure-chemical ionization mass spectrometry permitted measurement of the release of the endogenous cannabinoid anandamide in the periaqueductal gray (PAG) by in vivo microdialysis in the rat. Electrical stimulation of the dorsal and… CONTINUE READING
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The release of anandamide in the PAG of the rat stimulated by electrical depolarization or pain

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