Pain mechanisms: labeled lines versus convergence in central processing.

@article{Craig2003PainML,
  title={Pain mechanisms: labeled lines versus convergence in central processing.},
  author={A. Craig},
  journal={Annual review of neuroscience},
  year={2003},
  volume={26},
  pages={
          1-30
        }
}
  • A. Craig
  • Published 2003
  • Psychology, Medicine
  • Annual review of neuroscience
  • The issue of whether pain is represented by specific neural elements or by patterned activity within a convergent somatosensory subsystem has been debated for over a century. The gate control theory introduced in 1965 denied central specificity, and since then most authors have endorsed convergent wide-dynamic-range neurons. Recent functional and anatomical findings provide compelling support for a new perspective that views pain in humans as a homeostatic emotion that integrates both specific… CONTINUE READING
    667 Citations

    Figures and Topics from this paper.

    A new view of pain as a homeostatic emotion
    • A. Craig
    • Psychology, Medicine
    • Trends in Neurosciences
    • 2003
    • 693
    Pain Processing Pathway Models
    • S. Prescott
    • Medicine, Computer Science
    • Encyclopedia of Computational Neuroscience
    • 2014
    • 3
    • Highly Influenced
    • PDF
    Evolution of Pain Pathways
    • 4
    Pain processing by spinal microcircuits: afferent combinatorics
    • 34
    • PDF
    Nonpeptidergic Circuits Feel Your Pain
    • 33
    Cortical Representation of Pain and Touch: Evidence from Combined Functional Neuroimaging and Electrophysiology in Non-human Primates
    • L. Chen
    • Psychology, Medicine
    • Neuroscience Bulletin
    • 2017
    • 9
    The insula: A multidimensional integration site for pain
    • 82
    Pain and emotion interactions in subregions of the cingulate gyrus
    • B. Vogt
    • Psychology, Medicine
    • Nature Reviews Neuroscience
    • 2005
    • 1,380
    • PDF
    Nociceptive processing in the human brain
    • I. Tracey
    • Psychology, Medicine
    • Current Opinion in Neurobiology
    • 2005
    • 239

    References

    SHOWING 1-10 OF 144 REFERENCES
    Pain-related neurons in the human cingulate cortex
    • 584
    Thermosensory activation of insular cortex
    • 845
    Thalamic relay site for cold perception in humans.
    • 117
    • PDF
    Is there a specific lamina I spinothalamocortical pathway for pain and temperature sensations in primates?
    • A. Craig, A. Blomqvist
    • Medicine
    • The journal of pain : official journal of the American Pain Society
    • 2002
    • 50
    The affective component of pain in rodents: Direct evidence for a contribution of the anterior cingulate cortex
    • 535
    • PDF
    Pain mechanisms: a new theory.
    • 2,138
    • PDF
    Why are Selectively Responsive and Multireceptive Neurons both Present in Somatosensory Pathways
    • 34
    • Highly Influential
    Role of thalamus in pain.
    • 49