Pain mechanisms: labeled lines versus convergence in central processing.
@article{Craig2003PainML,
title={Pain mechanisms: labeled lines versus convergence in central processing.},
author={A. D. Craig},
journal={Annual review of neuroscience},
year={2003},
volume={26},
pages={
1-30
}
}The issue of whether pain is represented by specific neural elements or by patterned activity within a convergent somatosensory subsystem has been debated for over a century. The gate control theory introduced in 1965 denied central specificity, and since then most authors have endorsed convergent wide-dynamic-range neurons. Recent functional and anatomical findings provide compelling support for a new perspective that views pain in humans as a homeostatic emotion that integrates both specific…
719 Citations
Pain Processing Pathway Models
- BiologyEncyclopedia of Computational Neuroscience
- 2014
The dorsal horn of the spinal cord, which corresponds to the first synaptic relay point, comprises a diverse set of interneurons whose connectivity is only partially worked out, and presents an opportunity for modeling to help guide future experiments.
Pain processing by spinal microcircuits: afferent combinatorics
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Cortical Representation of Pain and Touch: Evidence from Combined Functional Neuroimaging and Electrophysiology in Non-human Primates
- Biology, PsychologyNeuroscience Bulletin
- 2017
Data is presented showing that the cortical circuitry engaged in nociceptive processing is much more complex than previously recognized, and has significant implications for using fMRI to study chronic pain conditions involving deafferentation in humans.
Pain and emotion interactions in subregions of the cingulate gyrus
- Biology, PsychologyNature Reviews Neuroscience
- 2005
This work assesses pain and emotion in each cingulate subregion, and assess whether pain is co-localized with negative affect, and finds that these activation patterns do not simply overlap.
Psychophysics of CNS Pain-Related Activity: Binary and Analog Channels and Memory Encoding
- Biology, PsychologyThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
- 2006
It is shown that stimulation of an STT receiving zone in awake humans produces two different exteroceptive responses, the first a binary response signaling the presence of painful stimuli and the second an analog response in which nonpainful and painful sensations are graded with intensity of the stimulus.
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