Pain mechanisms: labeled lines versus convergence in central processing.

@article{Craig2003PainML,
  title={Pain mechanisms: labeled lines versus convergence in central processing.},
  author={A. Craig},
  journal={Annual review of neuroscience},
  year={2003},
  volume={26},
  pages={
          1-30
        }
}
  • A. Craig
  • Published 2003
  • Psychology, Medicine
  • Annual review of neuroscience
The issue of whether pain is represented by specific neural elements or by patterned activity within a convergent somatosensory subsystem has been debated for over a century. The gate control theory introduced in 1965 denied central specificity, and since then most authors have endorsed convergent wide-dynamic-range neurons. Recent functional and anatomical findings provide compelling support for a new perspective that views pain in humans as a homeostatic emotion that integrates both specific… Expand
View on PubMed
pain.anes.pitt.edu
693 Citations
Highly Influential Citations
53
Background Citations
320
Methods Citations
9
Results Citations
18

Figures and Topics from this paper

693 Citations

Citation Type

Citation Type

A new view of pain as a homeostatic emotion
  • A. Craig
  • Medicine, Psychology
  • Trends in Neurosciences
  • 2003
TLDR
These findings indicate that the human feeling of pain is both a distinct sensation and a motivation - that is, a specific emotion that reflects homeostatic behavioral drive, similar to temperature, itch, hunger and thirst. Expand
Somatosensory Pathways (Ascending): Functional Architecture
Anatomical, electrophysiological, and more recently, functional imaging studies have been shown that the processing of somatosensory information involves a number of structures in the brain. The idea… Expand
Pain Processing Pathway Models
  • S. Prescott
  • Medicine, Computer Science
  • Encyclopedia of Computational Neuroscience
  • 2014
TLDR
The dorsal horn of the spinal cord, which corresponds to the first synaptic relay point, comprises a diverse set of interneurons whose connectivity is only partially worked out, and presents an opportunity for modeling to help guide future experiments. Expand
Evolution of Pain Pathways
The human pain pathway evolved from an afferent representation of the physiological condition of the body, present in all vertebrates, that provides spinal and brainstem regions involved in… Expand
Pain processing by spinal microcircuits: afferent combinatorics
TLDR
It is outlined how peripheral specialization together with central convergence could enable spinal microcircuits to combine inputs from distinctly specialized, co-activated afferents and to modulate the output signals thus formed through computations like normalization. Expand
Nonpeptidergic Circuits Feel Your Pain
TLDR
This issue of Neuron, Braz and colleagues genetically targeted the transneuronal tract tracer wheat germ agglutinin to nonpeptidergic nociceptive neurons and found that these neurons give rise to a specialized multisynaptic circuit that links pain signals in the periphery to limbic/affective regions of the brain. Expand
Cortical Representation of Pain and Touch: Evidence from Combined Functional Neuroimaging and Electrophysiology in Non-human Primates
  • L. Chen
  • Psychology, Medicine
  • Neuroscience Bulletin
  • 2017
TLDR
Data is presented showing that the cortical circuitry engaged in nociceptive processing is much more complex than previously recognized, and has significant implications for using fMRI to study chronic pain conditions involving deafferentation in humans. Expand
The insula: A multidimensional integration site for pain
Tracer and imaging studies have revealed patterns of connectivity relevant to pain processing within the mammalian central nervous system (Craig et al., 2002; Braz et al., 2005; Hadjipavlou et al.,… Expand
Pain and emotion interactions in subregions of the cingulate gyrus
  • B. Vogt
  • Psychology, Medicine
  • Nature Reviews Neuroscience
  • 2005
TLDR
This work assesses pain and emotion in each cingulate subregion, and assess whether pain is co-localized with negative affect, and finds that these activation patterns do not simply overlap. Expand
Psychophysics of CNS Pain-Related Activity: Binary and Analog Channels and Memory Encoding
TLDR
It is shown that stimulation of an STT receiving zone in awake humans produces two different exteroceptive responses, the first a binary response signaling the presence of painful stimuli and the second an analog response in which nonpainful and painful sensations are graded with intensity of the stimulus. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 144 REFERENCES
Pain-related neurons in the human cingulate cortex
TLDR
This work has identified single neurons in ACC that respond selectively to painful thermal and mechanical stimuli, supporting a role for the ACC in pain perception. Expand
Pain affect encoded in human anterior cingulate but not somatosensory cortex.
TLDR
These findings provide direct experimental evidence in humans linking frontal-lobe limbic activity with pain affect, as originally suggested by early clinical lesion studies. Expand
Thermosensory activation of insular cortex
TLDR
Using positron emission tomography, it is found contralateral activity correlated with graded cooling stimuli only in the dorsal margin of the middle/posterior insula in humans, which supports the proposal that central pain results from loss of the normal inhibition of pain by cold. Expand
Thalamic relay site for cold perception in humans.
TLDR
Data provide the first direct demonstration of a pathway mediating cold sensation and its location in the human thalamus and at some of these sites thalamic neurons were found that responded to innocuous cooling of the skin area corresponding to the stimulation-evoked cold sensations. Expand
Is there a specific lamina I spinothalamocortical pathway for pain and temperature sensations in primates?
  • A. Craig, A. Blomqvist
  • Medicine
  • The journal of pain : official journal of the American Pain Society
  • 2002
TLDR
The evidence indicates a view of ascending pain pathways that is conceptually distinct from Willis et al's view, as well as addressing a few major issues raised in their article. Expand
Why are Selectively Responsive and Multireceptive Neurons both Present in Somatosensory Pathways
It is a particular privilege to join in this symposium honoring Yngve Zotterman. His gracious hospitality and enthusiasm for science was an inspiration to me as to so many others. My invitation asked… Expand
The affective component of pain in rodents: Direct evidence for a contribution of the anterior cingulate cortex
TLDR
Evidence is provided indicating that neurons in the ACC are necessary for the “aversiveness” of nociceptor stimulation by measuring a learned behavior that directly reflects the affective component of pain in the rat. Expand
Role of thalamus in pain.
TLDR
The present data indicates that bursting activity is a more general phenomenon occurring in other patient groups, and nociceptive neurons in the pain pathway that are normally silent started to fire in a bursting fashion as a result of pathological changes, then this could explain the occurrence of chronic pain. Expand
Pain mechanisms: a new theory.
TLDR
A new theory of pain mechanisms is proposed, which holds that the nerve impulse pattern for pain is produced by intense stimulation of nonspecific receptors since "there are no specific fibers and no apecific endings". Expand
Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn.
HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent… Expand
...
1
2
3
4
5
...