Pain management in the Ehlers–Danlos syndromes

  title={Pain management in the Ehlers–Danlos syndromes},
  author={Pradeep Jagdish Chopra and Brad T Tinkle and Claude Hamonet and Isabelle Brock and Anne Gompel and Antonio Bulbena and Clair A Francomano},
  journal={American Journal of Medical Genetics Part C: Seminars in Medical Genetics},
  pages={212 - 219}
Chronic pain in the Ehlers–Danlos syndromes (EDS) is common and may be severe. According to one study, nearly 90% of patients report some form of chronic pain. Pain, which is often one of the first symptoms to occur, may be widespread or localized to one region such as an arm or a leg. Studies on treatment modalities are few and insufficient to guide management. The following is a discussion of the evidence regarding the underlying mechanisms of pain in EDS. The causes of pain in this condition… 

Management of chronic pain in Ehlers–Danlos syndrome

Two case reports of EDS patients with chronic pain are illustrated and the relevant literature regarding the pathological considerations and management of chronic pain in EDS is reviewed.

Pain Symptomatology and Management in Pediatric Ehlers–Danlos Syndrome: A Review

Research to date on pain characteristics and management, and the relationship between such pain symptomatology and quality of life in pediatric EDS are summarized, highlighting the need for additional research related to pediatric pain management in the context of hypermobility syndromes.

Multidisciplinary chronic pain management strategies in patients with Ehlers-Danlos syndromes.

This study reviews two cases of chronic pain in h EDS patients and the multimodal treatment regimen used along with peripheral nerve stimulation for shoulder and knee pains, never before reported in hEDS patients.

Multidisciplinary Approach to Treating Chronic Pain in Patients with Ehlers–Danlos Syndrome: Critically Appraised Topic

Weak evidence to support the efficacy of the individual components of the conservative multidisciplinary approach in patients with Ehlers-Danlos Syndrome and Pain Management is provided.

Ehlers-Danlos Syndrome: An Analysis of the Current Treatment Options

Although this study is able to identify positive and negative trends with certain modalities, it is vital to understand that EDS is not a uniform diagnosis among patients, and that a combination of several different treatments usually is needed for optimal symptom control.

Systemic manifestations of Ehlers-Danlos syndrome

A better understanding of Ehlers-Danlos syndrome is provided to promote earlier and more accurate diagnoses to guide treatment and prevent complications and to investigate the demographic characteristics and systemic manifestations in EDS.

SyndromeHypermobility Spectrum Disorder and Ehlers-Danlos Chronic Low Back Pain Occurring in Association With

Background: This review paper outlines recent advances in diagnostic criteria for hypermobility spectrum disorder (HSD) and its association with Ehlers-Danlos syndrome (EDS), as well as current

Ehlers-Danlos Syndrome in the Field of Psychiatry: A Review

Ehlers-Danlos syndrome (EDS) comprises a series of rare hereditary connective tissue diseases characterized by joint hypermobility, joint dislocation, and hyperextensibility of the skin, as well as

Cognitive, emotional, and behavioral considerations for chronic pain management in the Ehlers–Danlos syndrome hypermobility-type: a narrative review

It is necessary to explore the psychosocial functioning of patients as part of the overall chronic pain management in the EDS hypermobility-type, especially when they do not respond to biomedical approaches as psychological factors may be operating against rehabilitation.

Chronic Low Back Pain Occurring in Association With Hypermobility Spectrum Disorder and Ehlers-Danlos Syndrome

ABSTRACT Background: This review paper outlines recent advances in diagnostic criteria for hypermobility spectrum disorder (HSD) and its association with Ehlers-Danlos syndrome (EDS), as well as



Pain in ehlers-danlos syndrome is common, severe, and associated with functional impairment.

Chronic pain is a manifestation of the Ehlers-Danlos syndrome.

Management of pain and fatigue in the joint hypermobility syndrome (a.k.a. Ehlers–Danlos syndrome, hypermobility type): Principles and proposal for a multidisciplinary approach

A practical classification of pain presentations and factors contributing in generating painful sensations in JHS/EDS‐HT is proposed and a set of lifestyle recommendations to instruct patients as well as specific investigations aimed at characterizing pain and fatigue are identified.

Chronic pain in patients with the hypermobility type of Ehlers–Danlos syndrome: evidence for generalized hyperalgesia

Evidence is provided for the existence of hyperalgesia even in asymptomatic areas (generalized secondary hyper algesia) in patients with the Ehlers–Danlos syndrome hypermobility type (EDS-HT), which inquires an adapted pain management for this patient group.

Ehlers–Danlos Syndrome—Hypermobility Type: A Much Neglected Multisystemic Disorder

The known manifestations of the extra-articular systems of Ehlers–Danlos syndrome-HT are described, including cardiovascular, autonomic nervous system, gastrointestinal, hematologic, ocular, gynecologic, neurologic, and psychiatric manifestations.

Both pain and fatigue are important possible determinants of disability in patients with the Ehlers-Danlos syndrome hypermobility type

The recently published study on pain in EDS replicated the findings of Rombaut et al. and provided some new insights in the role of pain in the different subtypes of EDS and showed that pain severity was a possible determinant of the level of disability.

Connective tissue, Ehlers–Danlos syndrome(s), and head and cervical pain

Assessment and management procedures are discussed in order to put some basis for ameliorating the actual patients' needs and nurturing future research.

Re‐writing the natural history of pain and related symptoms in the joint hypermobility syndrome/Ehlers–Danlos syndrome, hypermobility type

The re‐writing of the natural history of JHS/EDS‐HT is aimed to raise awareness among clinical geneticists and specialists treating chronic pain conditions about pain and other complications of JHP, and symptoms' clustering by disease stage is proposed.