Pain in neuropsychiatry: Insights from animal models

  title={Pain in neuropsychiatry: Insights from animal models},
  author={Lidia Bravo and Meritxell Llorca-Torralba and Irene Su{\'a}rez-Pereira and Esther Berrocoso},
  journal={Neuroscience \& Biobehavioral Reviews},
Pain is the most common symptom reported in clinical practice, meaning that it is associated with many pathologies as either the origin or a consequence of other illnesses. Furthermore, pain is a complex emotional and sensorial experience, as the correspondence between pain and body damage varies considerably. While these issues are widely acknowledged in clinical pain research, until recently they have not been extensively considered when exploring animal models, important tools for… Expand
Comorbid Chronic Pain and Depression: Shared Risk Factors and Differential Antidepressant Effectiveness
Treatment response analyses indicate differential effectiveness between particular antidepressants and poorer functional outcomes for these comorbid conditions and this work will advance the delineation of disease risk indicators and novel aetiological pathways for therapeutic intervention inComorbid pain and depression as well as other psychiatric Comorbidities. Expand
Long-lasting analgesic and neuroprotective action of the non-benzodiazepine anxiolytic etifoxine in a mouse model of neuropathic pain
This study suggests that EFX presents promising therapeutic potential for the relief of both somatosensory and affective consequences of neuropathic pain, a beneficial effect that is likely to involve monoamine descending controls. Expand
The Antagonism of the Prokineticin System Counteracts Bortezomib Induced Side Effects: Focus on Mood Alterations
BTZ treated neuropathic mice develop anxiety and depression and the therapeutic treatment with the antagonist of the prokineticin (PK) system PC1 prevented the development of supraspinal inflammation and depression-like behavior in BTZ mice. Expand
Neuropathic pain increases spontaneous and noxious-evoked activity of locus coeruleus neurons
Long-term nerve injury led to higher spontaneous activity and exacerbated noxious-evoked responses in the locus coeruleus to stimulation of nerve-injured and even uninjured hindpaws, coinciding temporally with the development of depressive and anxiogenic-like behavior. Expand
Pra-C exerts analgesic effect through inhibiting microglial activation in anterior cingulate cortex in complete Freund’s adjuvant-induced mouse model
Pra-C administration had a certain effect on relieving chronic pain by inhibiting microglial activation, attenuating proinflammatory cytokine releasing and regulating excitatory synaptic proteins in the ACC of the CFA-injected mice. Expand
Mechanisms Regulating Transient Receptor Potential Cation Channel A1 (TRPA1) and Their Roles in Nociception and Nociceptive Sensitization
Nociception is the sensory nervous system that detects harmful stimuli including excessive heat, cold, toxic chemicals, and noxious mechanical stimulations. Transient receptor potential (TRP)Expand


The anxiodepressive comorbidity in chronic pain
Better understanding of the genetic and environmental determinants of pain-induced mood disorders and of the various neurobiological bases of this comorbidity depending on the pain subtype could provide the clinician with important diagnosis and treatment tools. Expand
Pain manifestations in schizophrenia - clinical and experimental aspects in human patients and animal models.
The importance of determining pain mechanism, its particularities and evolution in the context of schizophrenic disease, so that this phenomenon could be evaluated, quantified and controlled with the intention of obtaining a superior management for this disorder and to possibly raise hopes of higher life quality and expectancy in patients suffering from schizophrenia. Expand
Psychiatric aspects of pain
  • O. Gureje
  • Medicine
  • Current opinion in psychiatry
  • 2007
Current understanding of the complexity of the link between chronic pain and mental disorders not only provides opportunities for designing appropriate interventions but also raises new questions for further research. Expand
Emotional consequences of neuropathic pain: Insight from preclinical studies
This review reports the preclinical evidences from anatomical, neuroimaging, behavioral, pharmacological and biochemical studies that address the anxiodepressive consequences of neuropathic pain and presents an overview of rodent models of these consequences. Expand
Preclinical research on pain comorbidity with affective disorders and cognitive deficits: Challenges and perspectives
This review summarizes and integrates previous reports of animal studies on pain and comorbidity, covering pain-evoked anxiety, depression, attentional deficits, cognitive impairment and locomotor dysfunction in rodents and points out some unresolved problems and future research directions. Expand
Pain perception in psychiatric disorders: a review of the literature.
The authors review the relevant experimental studies on pain perception in patients with anxiety disorders, schizophrenia, depression, eating disorders and personality disorders, and point out that the experimental study of pain perception is useful not only in understanding aberrant pain experiences in psychiatric disorders but also in elucidating pathophysiological mechanisms. Expand
Pain perception in major depressive disorder: A neurophysiological case–control study
The pain threshold and pain tolerance were lower in patients with major depression than controls than controls, suggesting the abnormal processing of pain stimuli in depressive disorders. Expand
Alcohol dependence as a chronic pain disorder
Evidence presented here supports the hypothesis that alcohol dependence is among the pathologies arising from aberrant neurobiological substrates of pain, and proposes an allostatic load model in which episodes of alcohol intoxication and withdrawal, traumatic stressors, and injury are each capable of dysregulating an overlapping set of neural substrates. Expand
The molecular neurobiology of chronic pain–induced depression
This review provides an overview of clinical and pre-clinical studies performed over the past two decades addressing the molecular aspects of the comorbid relationship of chronic pain and depression, especially major depressive disorders, from the genetic and epigenetic point of view to key neuromodulators. Expand
Pain perception in major depression depends on pain modality
The main finding suggests that painful stimuli are processed differentially depending on the localization of pain induction in depression, which may enable us to understand and ultimately treat pain complaints more appropriately in depressed patients. Expand