Pain in fibrous dysplasia of bone: age-related changes and the anatomical distribution of skeletal lesions

@article{Kelly2007PainIF,
  title={Pain in fibrous dysplasia of bone: age-related changes and the anatomical distribution of skeletal lesions},
  author={Marilyn H. Kelly and Beth A. Brillante and M. T. Collins},
  journal={Osteoporosis International},
  year={2007},
  volume={19},
  pages={57-63}
}
SummaryTo determine the prevalence, distribution, age-related changes and treatment of pain in fibrous dysplasia, we studied 78 children and adults. Pain was common, more prevalent and intense in adults, sometimes requiring narcotic analgesia. It was often untreated, especially in children, and surprisingly severity did not correlate with skeletal disease burden.IntroductionPain is common in fibrous dysplasia (FD), but relatively unstudied. We studied a well-characterized population of patients… 
Pain in fibrous dysplasia: relationship with anatomical and clinical features
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The data suggest that almost 50% of patients with FD report pain at FD sites, thus representing a major clinical manifestation of the disorder, importantly also in patients with monostotic lesions.
Preliminary Results of Curettage and Cementation in the Treatment of Fibrous Dysplasia of the Proximal Radius
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To use curettage and cementation as a control method of Fibrous dysplasia of the proximal radius, a relatively common, benign developmental skeletal disorder, female patients may have an increase in pain or even an increased tendency to fracture during and immediately after pregnancy, and treatment is mainly palliative.
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TLDR
The mechanism of bone pain in FD remains uncertain, but by analogy with bone tumors one may consider that ectopic sprouting and formation of neuroma-like structures by sensory and sympathetic nerve fibers also occur in the dysplastic skeleton.
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Determinants of impaired quality of life in patients with fibrous dysplasia
BackgroundFibrous dysplasia is a rare bone disorder, commonly associated with pain, deformity and fractures, which may significantly impact on quality of life. In this study we evaluate quality of
Natural History and Progression of Craniofacial Fibrous Dysplasia: A Retrospective Evaluation of 114 Patients From Massachusetts General Hospital.
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Monostotic fibrous dysplasia of the proximal femur: natural history and predisposing factors for disease progression.
TLDR
The natural history and predisposing factors for progression of dysplasia in a group of 76 patients with a mean follow-up of 8.5 years were investigated, finding an initial presentation of pain, a limp, radiological evidence of microfracture, and younger age (< 17 years) were significant predispose factors for disease progression.
The Hip in Fibrous Dysplasia
TLDR
The managed of FD of the proximal femur aims at preventing pathologic fracture, deformity correction, and pain control, and once skeletal maturity is reached the disease process tends to stabilize or may normalize in select patients.
Prognostic Factors From an Epidemiologic Evaluation of Fibrous Dysplasia of Bone in a Modern Cohort: The FRANCEDYS Study
TLDR
In a national referral center for FD, one patient on follow‐up out of six had incident fracture, and in the multivariate model, the polyostotic form and bisphosphonate use remained significant predictors.
Age‐Related Changes and Effects of Bisphosphonates on Bone Turnover and Disease Progression in Fibrous Dysplasia of Bone
  • P. Florenzano, Kristen S. Pan, A. Boyce
  • Medicine, Biology
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2019
TLDR
FD is associated with an age‐dependent decline in bone turnover and other markers of disease activity and its association with pain, which should be considered when evaluating use and response to bisphosphonates in patients being treated for FD and in any study using BTMs as surrogate endpoints.
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