Pain in amyotrophic lateral sclerosis

  title={Pain in amyotrophic lateral sclerosis},
  author={Adriano Chi{\`o} and Gabriele Mora and Giuseppe Lauria},
  journal={The Lancet Neurology},

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Pain in amyotrophic lateral sclerosis: a narrative review

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The development of standardized and specific assessment tools for pain-specific to ALS is required, as are further studies on treatments to reduce pain, diminish suffering, and improve the quality of life of patients with ALS.

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The use of viral vectors to express transgenes that modulate the nociceptive cascade could prove to be an effective way to achieve meaningful benefit in conditions of pain in ALS.

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Even if amyotrophic lateral sclerosis is a disease of the motor system, pain is frequent and can rarely have neuropathic characteristics, and pain must be always sought and appropriately treated to limit quality of life impairment.

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No randomised or quasi-randomised controlled trials on drug therapy for pain in ALS or MND were found and further research on this important aspect of palliative care in ALS is needed.

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Results indicate the importance of clinical investigation of pain in ALS patients and of the intervention with anti-pain treatment whenever necessary.

Chronic pain syndrome in amyotrophic lateral sclerosis.

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This report concerns a patient with clinically and electromyographically typical ALS in whom a concomitant chronic central pain syndrome developed, for which no additional cause could be found.

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