Pain in amyotrophic lateral sclerosis

@article{Chi2017PainIA,
  title={Pain in amyotrophic lateral sclerosis},
  author={Adriano Chi{\`o} and Gabriele Mora and Giuseppe Lauria},
  journal={The Lancet Neurology},
  year={2017},
  volume={16},
  pages={144-157}
}
Pain is a largely neglected symptom in patients with amyotrophic lateral sclerosis (ALS) although it is reported by most of these patients. It occurs at all stages of the disease and can be an onset symptom preceding motor dysfunction. Pain is correlated with a deterioration in patients' quality of life and increased prevalence of depression. In the later stages of ALS, pain can be severe enough to require increased use of sedative and analgesic drugs, and is among the events that predict… 
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