Pain complaints in patients with fibromyalgia versus chronic fatigue syndrome

  title={Pain complaints in patients with fibromyalgia versus chronic fatigue syndrome},
  author={Laurence A Bradley and Nancy L. McKendree-Smith and Graciela S Alarc{\'o}n},
  journal={Current Review of Pain},
Individuals with fibromyalgia (FM) and/or chronic fatigue syndrome (CFS) report arthralgias and myalgias. However, only persons with FM alone exhibit abnormal pain responses to mild levels of stimulation, or allodynia. We identify the abnormalities in the neuroendocrine axes that are common to FM and CFS as well as the abnormalities in central neuropeptide levels and functional brain activity that differentiate these disorders. These two sets of factors, respectively, may account for the… 

Recovery of upper limb muscle function in chronic fatigue syndrome with and without fibromyalgia

Recovery of upper limb muscle function from a fatiguing exercise in CFS patients with (CFS+FM) and without (C FS‐only) comorbid fibromyalgia are examined and their results are compared with a matched inactive control group.

Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome

The hypothesis that central sensitization is also responsible for the sustaining pain complaints in CFS is proposed, based on the hyperalgesia and allodynia reported in C FS, on the elevated concentrations of nitric oxide presented in the blood of CFS patients, in addition to the typical personality styles seen in Cfs and on the brain abnormalities shown on brain images.

Hypothalamic-Pituitary-Adrenal Axis Function in Fibromyalgia and Chronic Fatigue Syndrome

Patients with chronic fatigue syndrome (CFS) or fibromyalgia, two prevalent and poorly understood disorders, experience symptoms of fatigue and myalgias that are reminiscent of those experienced by

Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study

Findings provide evidence for the existence of hyperalgesia even in asymptomatic areas (generalized secondary hyperAlgesia) in chronic fatigue syndrome, which may represent the involvement of a sensitized central nervous system.

Functional somatic syndrome: how it could be relevant to rheumatologists

The authors introduce the concept of FSS focusing on its possible relevance to rheumatology in terms of pain perception and a possible implication of mast cells and proteinase-activated receptor-2 (PAR-2) in FSS is reviewed.

SP0062 Fibromyalgia: evidence for a central nervous system disorder

Findings indicate that FM patients show abnormal central processing of nociceptive stimuli that tends to be exacerbated by stress, and may be mediated by abnormal cortisol release or cytokine production.

Temporomandibular Disorders and its Relationship with Fibromyalgia

The characteristics and the relationship between TMD and FMS are reviewed, highlighting the importance of this comorbid condition for the management of TMD.

Numeric Rating Scales Show Prolonged Post-exertional Symptoms After Orthostatic Testing of Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

NRS scores of pain, fatigue, and concentration were significantly increased even at 7 days post-HUT compared with pre-H UT in ME/CFS patients with and without FM, suggesting that orthostatic stress is an important determinant of PEM.



Fibromyalgia and chronic fatigue syndrome: similarities and differences.

  • D. Buchwald
  • Psychology, Medicine
    Rheumatic diseases clinics of North America
  • 1996

Current concepts in the pathophysiology of abnormal pain perception in fibromyalgia.

Recent data supporting the links among each of three systems--the musculoskeletal system, the neuroendocrine system, and the central nervous system--are reviewed, and a model of the pathophysiology of abnormal pain perception in fibromyalgia is presented which integrates the research findings described.

Chronic fatigue syndrome and fibromyalgia. Dilemmas in diagnosis and clinical management.

  • M. Demitrack
  • Medicine, Psychology
    The Psychiatric clinics of North America
  • 1998

Comparison of patients with chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivities.

Demographic and clinical factors and health locus of control do not clearly distinguish patients with CFS, FM, and MCS.

Fibromyalgia and major affective disorder: a controlled phenomenology and family history study.

Both the rate of major affective disorder and the familial prevalence of major Affective disorder were significantly higher in the fibromyalgia patients than the rheumatoid arthritis patients.

Somatization and depression in fibromyalgia syndrome.

Fibromyalgia patients exhibited a pattern of reporting more somatic symptoms, multiple surgical procedures, and help seeking that may reflect a process of somatization rather than a discrete psychiatric disorder.

Does primary fibromyalgia exist?

Twenty-one of 25 consecutive primary fibromyalgia or fibrositis patients, identified during a 5-year period in a tertiary care day-ward for pain syndromes, were re-examined and none of the patients has been able to return to full time work.