Pain and the neuromatrix in the brain.

@article{Melzack2001PainAT,
  title={Pain and the neuromatrix in the brain.},
  author={Ronald Melzack},
  journal={Journal of dental education},
  year={2001},
  volume={65 12},
  pages={1378-82}
}
The neuromatrix theory of pain proposes that pain is a multidimensional experience produced by characteristic "neurosignature" patterns of nerve impulses generated by a widely distributed neural network-the "body-self neuromatrix"-in the brain. These neurosignature patterns may be triggered by sensory inputs, but they may also be generated independently of them. Acute pains evoked by brief noxious inputs have been meticulously investigated by neuroscientists, and their sensory transmission… CONTINUE READING