Pain and purinergic signaling

  title={Pain and purinergic signaling},
  author={Makoto Tsuda and Hidetoshi Tozaki-Saitoh and Kazuhide Inoue},
  journal={Brain Research Reviews},
A growing body of evidence indicates that extracellular nucleotides play important roles in the regulation of neuronal and glial functions in the nervous system through P2 purinoceptors. P2 purinoceptors are divided into two families, ionotropic receptors (P2X) and metabotropic receptors (P2Y). P2X receptors (seven types; P2X1-P2X7) contain intrinsic pores that open by binding with ATP, and P2Y receptors (eight types; P2Y1, 2, 4, 6, 11, 12, 13 and 14) are activated by nucleotides and couple to… CONTINUE READING


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