Pain and immunity: implications for host defence

@article{Baral2019PainAI,
  title={Pain and immunity: implications for host defence},
  author={Pankaj Baral and Swalpa Udit and Isaac M Chiu},
  journal={Nature Reviews Immunology},
  year={2019},
  pages={1-15}
}
Pain is a hallmark of tissue injury, inflammatory diseases, pathogen invasion and neuropathy. It is mediated by nociceptor sensory neurons that innervate the skin, joints, bones, muscles and mucosal tissues and protects organisms from noxious stimuli. Nociceptors are sensitized by inflammatory mediators produced by the immune system, including cytokines, lipid mediators and growth factors, and can also directly detect pathogens and their secreted products to produce pain during infection. Upon… CONTINUE READING
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