Pain and Opioid Addiction: What is the Connection?

  title={Pain and Opioid Addiction: What is the Connection?},
  author={Adam J. Carinci and Jianren Mao},
  journal={Current Pain and Headache Reports},
  • A. Carinci, J. Mao
  • Published 10 January 2010
  • Psychology, Biology, Medicine
  • Current Pain and Headache Reports
Addiction to opioid analgesics is an important and yet underinvestigated clinical issue, which has substantial implications in opioid therapy for chronic pain management. Problematic opioid use, including compulsive opioid seeking and addiction, arises in some fraction of opioid-treated chronic pain patients. The connection between chronic pain and opioid addiction is a complex interplay between psychological, epidemiological, and neurobiological factors. Herein, we explore this critical… 
Switching off pain at the source: is this the end for opioid pain relief?
A new technical approach is described that may be useful for the prolonged suppression of nociceptive pain by using a harmless adeno-associated virus carrying a short hairpin RNA to silence Nav1.7 ion channels only in sensory neurons underlying pain perception.
Abuse-deterrent opioid analgesics: a guide for clinicians.
This review summarizes the regulatory issues involved in the development of ADF opioids and clarifies abuse-deterrence claims in product labels, in order to assist clinicians in critically evaluating the available evidence pertaining to the abuse-Deterrent features of opioid analgesics.
The missing p in psychiatric training: why it is important to teach pain to psychiatrists.
Pain training in psychiatry will contribute to deeper and more sophisticated insight into both pain syndromes and general psychiatric morbidity regardless of patients' pain status and ease the artificial boundaries separating psychiatric and medical formulations of brain disorders, thus fostering cross-fertilizing interactions among specialists in various disciplines entrusted with the care of patients experiencing pain.
Opioid and healthcare service use in medical cannabis patients with chronic pain: a prospective study
Patients filled less opioid prescription medication at follow-up compared with baseline, and the reduction was of small effect size, suggesting that MC may be related to a significant yet small reduction in opioid prescription medications.
Bibliography of Drug, Substance and Alcoholic Abuse
The aim of this work is to enrich the discourse on the aforementioned issues by articulating in one piece, diverse reference sources on various sub-themes relating to them globally. This will
Improving Public Health Through Access to and Utilization of Medication Assisted Treatment
  • T. Kresina, Robert Lubran
  • Medicine, Political Science
    International journal of environmental research and public health
  • 2011
Developing a continuum of care for patients with opioid dependence throughout the stages MAT enhances the public health and Recovery from opioid dependence.
Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads.
Design and Synthesis of Conformationally Constrained Compounds as New Tramadol- like Candidates
The author reveals how different pharmacological interventions through distinct analgesic mechanisms of action approaches multiple mechanisms of pain signaling and modulation in the context of multidrug analgesic combination therapy and multitarget approach.
A shiftable gear transmission has a plurality of gear pairs with free gears that can be engaged to one of the shafts by means of shift clutches and fixed gears that are permanently locked to one of


Opioids and the treatment of chronic pain: controversies, current status, and future directions.
A narrative review briefly describes the neurobiology of opioids and focuses on the complex issues at this interface between analgesia and abuse, including terminology, clinical challenges, and the potential for new agents, such as buprenorphine, to influence practice.
Pain and addiction: an urgent need for change in nursing education.
Issues in long-term opioid therapy: unmet needs, risks, and solutions.
Changing patterns in opioid addiction: characterizing users of oxycodone and other opioids.
The substantial comorbid pain, psychiatric symptoms, and other psychoactive substance use problems in these patients, coupled with the finding that prescriptions were an important source of opioids, highlight the clinical complexities encountered in the treatment of these individuals.
Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain.
Drug Abuse, Dependence, and Addiction in Chronic Pain Patients
It is concluded that these diagnoses occur in a significant percentage of chronic pain patients, and there is little evidence in these studies that addictive behaviors are common within the chronic pain population.
Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects
Weak and strong opioids outperformed placebo for pain and function in all types of CNCP and were significantly superior to naproxen and nortriptyline, and only for pain relief.