Pain: morphine, metabolites, mambas, and mutations

@article{Woolf2013PainMM,
  title={Pain: morphine, metabolites, mambas, and mutations},
  author={Clifford J. Woolf},
  journal={The Lancet Neurology},
  year={2013},
  volume={12},
  pages={18-20}
}
  • C. Woolf
  • Published 31 January 2013
  • Medicine, Psychology
  • The Lancet Neurology
View on Elsevier
doi.org
11 Citations
Background Citations
5

11 Citations

Human pain in a dish: Native DRG neurons and differentiated pluripotent stem cells
Breaking barriers to novel analgesic drug development
TLDR
Recent advances in the understanding of the neurobiology of pain are beginning to offer opportunities for developing novel therapeutic strategies and revisiting existing targets, including modulating ion channels, enzymes and G-protein-coupled receptors.
Cannabinoid Receptor Type 1 and Its Role as an Analgesic: An Opioid Alternative?
TLDR
Evidence is provided that one of the main roles of the endocannabinoid system is the regulation of gamma-aminobutyric acid (GABA) and/or glutamate release and its implications for pain.
[Acid-Sensing Ion Channels (ASICs) in pain].
TLDR
The discovery of new drug targets represents a real opportunity for developing fresh strategies against pain and data suggesting a role in human pain suggests the therapeutic potential of acid-Sensing Ion Channels.
Binding Site and Inhibitory Mechanism of the Mambalgin-2 Pain-relieving Peptide on Acid-sensing Ion Channel 1a*
TLDR
A model where mambalgin-2 traps the channel in a closed conformation by precluding the conformational change of the palm and β-ball domains that follows proton activation is proposed.
Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition*
TLDR
The first full stepwise solid phase peptide synthesis of mambalgin-1 is shown and the biological activity of the synthetic toxin both in vitro and in vivo is confirmed and the determination of its three-dimensional crystal structure showing differences with previously described NMR structures is reported.
Acupuncture for Pediatric Pain
TLDR
Acupuncture can be an effective adjuvant in the care of pediatric patients with painful conditions, both in a chronic and an acute setting, and further studies, including randomized controlled trials, as well as trials of comparative effectiveness are needed.
Primary afferent input critical for maintaining spontaneous pain in peripheral neuropathy
Medical Science Turns Deadly Substances into Life Saving Ones: Snake Venom as a Treatment Option
TLDR
The aim of current research is to make people realize that the snake venom, despite being a deadly poison, may prove to be a treatment option in several rather incurable diseases.
Perioperative management in children with chronic pain
TLDR
Identification of the pediatric chronic pain patient preoperatively and development of a perioperative pain plan may help ensure a safer and more comfortable perioperatively course.
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