Paget disease: when to treat and when not to treat

  title={Paget disease: when to treat and when not to treat},
  author={Frederick R. Singer},
  journal={Nature Reviews Rheumatology},
Paget disease of bone is a focal disorder of the skeleton that can affect one or more bones. Many patients are discovered accidentally because of elevated serum alkaline phosphatase activity or an abnormal skeletal radiograph intended to evaluate an unrelated condition. Patients are often asymptomatic, but a subset experience considerable morbidity that can include bone pain and skeletal deformity, as well as a variety of regional complications, such as hearing loss associated with cranial… CONTINUE READING