Paeoniflorin reduced acute toxicity of aconitine in rats is associated with the pharmacokinetic alteration of aconitine.

@article{Fan2012PaeoniflorinRA,
  title={Paeoniflorin reduced acute toxicity of aconitine in rats is associated with the pharmacokinetic alteration of aconitine.},
  author={Yan Fang Fan and Ying Xie and Liang Liu and Hing Man Ho and Yuen Fan Wong and Zhong Qiu Liu and Hua Zhou},
  journal={Journal of ethnopharmacology},
  year={2012},
  volume={141 2},
  pages={701-8}
}
ETHNOPHARMACOLOGICAL RELEVANCE To investigate the influence of paeoniflorin (major bioactive component of Paeonia lactiflora Pall.) on the pharmacokinetic behavior of aconitine (major toxic and bioactive component of Aconitum carmichaeli Debx.) and potential detoxifying effect of paeoniflorin on the acute toxicity of aconitine, which may provide in depth understanding to the toxicity reduction effect of Paeonia lactiflora to Aconitum carmichaeli. MATERIALS AND METHODS Ultra high performance… CONTINUE READING