Paeoniflorin attenuates learning impairment of aged rats in operant brightness discrimination task

@article{Ohta1994PaeoniflorinAL,
  title={Paeoniflorin attenuates learning impairment of aged rats in operant brightness discrimination task},
  author={Hidehiko Ohta and Kinzo Matsumoto and Masanao Shimizu and Hiroshi Watanabe},
  journal={Pharmacology Biochemistry and Behavior},
  year={1994},
  volume={49},
  pages={213-217}
}
The effects of paeoniflorin isolated from peony were examined on an aging-induced learning deficit in an operant brightness discrimination task in Fischer 344 rats. Learning in aged (25 months) rats was significantly impaired compared with young (5 months) rats. Daily administration of paeoniflorin (0.01 mg/kg, PO) significantly attenuated the learning impairment in aged rats, whereas it did not affect the learning in young rats. Although tacrine (0.3 and 1 mg/kg, IP), a cholinesterase… CONTINUE READING

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