Paenilamicin: structure and biosynthesis of a hybrid nonribosomal peptide/polyketide antibiotic from the bee pathogen Paenibacillus larvae.

@article{Mller2014PaenilamicinSA,
  title={Paenilamicin: structure and biosynthesis of a hybrid nonribosomal peptide/polyketide antibiotic from the bee pathogen Paenibacillus larvae.},
  author={Sebastian M{\"u}ller and Eva Garcia-Gonzalez and Andi Mainz and Gillian Hertlein and Nina C Heid and Eva M{\"o}sker and Hans van den Elst and Herman S Overkleeft and Elke Genersch and Roderich D S{\"u}ssmuth},
  journal={Angewandte Chemie},
  year={2014},
  volume={53 40},
  pages={10821-5}
}
The spore-forming bacterium Paenibacillus larvae is the causative agent of American Foulbrood (AFB), a fatal disease of honey bees that occurs worldwide. Previously, we identified a complex hybrid nonribosomal peptide/polyketide synthesis (NRPS/PKS) gene cluster in the genome of P. larvae. Herein, we present the isolation and structure elucidation of the… CONTINUE READING

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