Paediatric non‐alcoholic fatty liver disease: an overview

  title={Paediatric non‐alcoholic fatty liver disease: an overview},
  author={Suzan A. AlKhater},
  journal={Obesity Reviews},
Non‐alcoholic fatty liver disease (NAFLD) is a progressive disease that encompasses a spectrum of liver diseases, ranging from simple steatosis to non‐alcoholic steatohepatitis (NASH). Data related to survival in children are scarce, but these data firmly associate NAFLD with higher risks of hepatic and non‐hepatic morbidities and mortalities compared with the general population. More recently, the association between NAFLD and cardiovascular disease among children has increasingly been… 


The epidemiology, risk factors, sign & symptoms diagnosis & finally draw a conclusion of nonalcoholic fatty liver disease are discussed.

Early life programming and the risk of non-alcoholic fatty liver disease

Data from animal models and human studies suggest that fetal and early life exposure to maternal under- and overnutrition, excess glucocorticoids and environmental pollutants may confer an increased susceptibility to NAFLD development and progression in offspring and that such effects may be sex-specific.

Nonalcoholic fatty liver disease in children and adolescents - Relationship with Polycystic Ovary Syndrome.

The present review aims to discuss recent findings of NAFLD in children and adolescents and, considering the features in common with PCOS, they also discuss their relationship.

Phospholipids in non-alcoholic fatty liver disease

It is very important to understand the mechanisms underlying the occurrence and development of NAFLD, the features of the clinic and diagnosis, as well as the tactics of management and treatment of patients with non-alcoholic fatty liver disease.

Fructose, Omega 3 Fatty Acids, and Vitamin E: Involvement in Pediatric Non-Alcoholic Fatty Liver Disease

The role of three key nutrients involved in pediatric NAFLD are discussed: fructose and its participation in metabolism, Omega-3 fatty acids and its anti-inflammatory effects and vitamin E and its action on oxidative stress.

Early Obesity: Risk Factor for Fatty Liver Disease.

The risk of developing NAFLD in adolescence increases progressively with early obesity starting at age 2 years, with obesity at 5 years of age associated with the highest OR.

Non-Alcoholic Fatty Liver Disease (NAFLD) in Children and Adolescents taking Atypical Antipsychotic Medications : A Protocol for a Systematic Review and Meta-Analysis

A systematic review following the PRISMA guidelines, of English-language literature published between 1950 and 2019, exploring NAFLD in subjects younger than 18 years on AAP, aimed to comprehensively examine the association between AAP and NAFLd in children and adolescents.

Nonalcoholic Fatty Liver Disease in Children and Adolescents Taking Atypical Antipsychotic Medications: Protocol for a Systematic Review and Meta-analysis

A systematic review of studies exploring NAFLD in subjects younger than 18 years on AAP published in English between 1950 and 2020 following the PRISMA guidelines is conducted.

Assessment of Dietary Patterns Among Patients Suffering From Fatty Liver Disease Attending Tertiary Care Hospitals, Lahore

It was concluded that less physical activity, consumption of fatty food, cold drinks and less intake of nutritional supplements were responsible for this disease.



Pediatric non alcoholic fatty liver disease: old and new concepts on development, progression, metabolic insight and potential treatment targets

This review provides an overview of current and new clinical-histological concepts of pediatric NAFLD, going through possible implications into patho-physiolocical and therapeutic perspectives.

A 360-degree overview of paediatric NAFLD: recent insights.

Nonalcoholic fatty liver disease: pathology and pathogenesis.

Nonalcoholic fatty liver disease is recognized as the leading cause of chronic liver disease in adults and children and is most closely linked with insulin resistance; the current Western diet, high in saturated fats and fructose, plays a significant role.

Nonalcoholic steatohepatitis in children

  • E. Roberts
  • Medicine
    Current gastroenterology reports
  • 2003
Although much remains to be learned about pediatric NAFLD, it is already evident that children with NASH risk progressive liver damage, including cirrhosis, and the incidence of this pediatric liver disease is rising as childhood obesity becomes increasingly prevalent.

Nonalcoholic fatty liver disease: From steatosis to cirrhosis

The present “gold standard” management of NASH is modest weight reduction, particularly correction of central obesity achieved by combining dietary measures with increased physical activity, which improves insulin resistance and reverses steatosis, hepatocellular injury, inflammation, and fibrosis.

Pediatric Nonalcoholic Fatty Liver Disease: A Critical Appraisal of Current Data and Implications for Future Research

The propensity for NASH to develop in obese, insulin-resistant pubertal boys of Hispanic ethnicity or a non-Hispanic white race may provide clues to the pathogenesis of NAFLD in children.

Non-alcoholic fatty liver disease in children now: lifestyle changes and pharmacologic treatments.

Diagnostic challenges of nonalcoholic fatty liver disease (NAFLD) in children of normal weight.

Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis

The evidence that suggests NAFLD is a multisystem disease and the factors that might determine interindividual variation in the development and progression of its major hepatic and extrahepatic manifestations are reviewed.