Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort

  title={Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort},
  author={Marie Pouletty and Charlotte Borocco and Naim Ouldali and Marion Caseris and Romain Basmaci and No{\'e}mie Lachaume and Philippe Bensaid and Samia Pichard and Hanane Kouider and Guillaume Morelle and Irina Craiu and Corinne Pondarr{\'e} and Anna Deh{\`o} and A. Maroni and Mehdi Oualha and Zahir Amoura and Julien Haroche and Juliette Chommeloux and Fanny Bajolle and Constance Beyler and St{\'e}phane Bonacorsi and Guislaine Carcelain and Isabelle Kon{\'e}-Paut and Brigitte Bader-Meunier and Albert Faye and Ulrich Meinzer and Caroline Galeotti and Isabelle Melki},
  journal={Annals of the Rheumatic Diseases},
  pages={999 - 1006}
Background Current data suggest that COVID-19 is less frequent in children, with a milder course. However, over the past weeks, an increase in the number of children presenting to hospitals in the greater Paris region with a phenotype resembling Kawasaki disease (KD) has led to an alert by the French national health authorities. Methods Multicentre compilation of patients with KD in Paris region since April 2020, associated with the detection of severe acute respiratory syndrome coronavirus 2… 

Correspondence on: ‘Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort’ by Pouletty et al

A prospective case series of paediatric patients that fulfilled clinical diagnostic criteria of KD during the SARS-CoV-2 pandemic in a paediatric referral centre in Barcelona, Spain is reported.

Correspondence on ‘Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort’

An adult who presented with KD-like illness similar to children in the Kawa-COVID-19 cohort 4 weeks following a documented SARS-CoV-2 infection is described.

Paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS): what does the future hold?

A multicentre cohort from Paris, which reported an increased incidence of Kawasaki disease like presentation in association with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection (Kawa-COVID-19) in children, found that no child was from the Asian race.

Response to: ‘Correspondence on ‘Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort’ by Pouletty et al’ by Pino et al

Consider Kawasaki syndrome associated with SARS-CoV-2 infection as a distinct entity, and the possibility of a common pathway shared with classic KD has led to administer similar therapeutics to KD, including intravenous immunoglobulins (IVIG) and corticosteroids.

SARS-CoV-2 Associated Pediatric Inflammatory Multisystem Syndrome With a High Prevalence of Myocarditis – A Multicenter Evaluation of Clinical and Laboratory Characteristics, Treatment and Outcome

Analysis of non-vaccinated children with PIMS-TS demonstrates that a considerable number have associated myocarditis requiring intensive care and inotropic support, and the impact of new virus variants are evaluated.

Paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS): a Brazilian cohort

This study showed a high morbidity of PIMS-TS in Brazilian children, with a prolonged length of hospitalization and a high rate of admission to pediatric intensive care unit.

Children with Kawasaki disease or Kawasaki-like syndrome (MIS-C/PIMS) at the time of COVID-19: are they all the same? Case series and literature review.

It is hypothesize that SARS-CoV-2 might act in children as a trigger, either inducing a classical KD phenotype or causing a systemic inflammatory response leading to a severe KD-like phenotype, eventually characterized by myocardial impairment.

Kawa-COVID-19 Storm: Multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2?

It is noted that children with COVID-19 are safe from developing the infection, as they suffer from simple symptoms in the upper respiratory system, as one study confirmed that out of 171 children infected with CO VID-19, only 3 children are required to enter into intensive care, with one death recorded.

The wide spectrum of Kawasaki-like disease associated with SARS-CoV-2 infection

Based on these findings, SARS-CoV-2 may be considered another trigger in the complex mosaic about the relationship among infectious agents and the occurrence of systemic hyper-inflammation related syndromes.



Acute Heart Failure in Multisystem Inflammatory Syndrome in Children in the Context of Global SARS-CoV-2 Pandemic

Children may experience an acute cardiac decompensation caused by severe inflammatory state after SARS-CoV-2 infection and the multisystem inflammatory syndrome in children as defined by the US Centers for Disease Control and Prevention.

SARS-CoV-2–Induced Kawasaki-Like Hyperinflammatory Syndrome: A Novel COVID Phenotype in Children

Patients with what is proposed to name as SARS-CoV-2–induced Kawasaki-like hyperinflammatory syndrome are described, which resembles Kawasaki disease complicated by macrophage activation syndrome, although it has peculiar features, such as prodromal diarrhea, capillary leak syndrome, and myocardial dysfunction.

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents: A Systematic Review.

This is the first systematic review that assesses and summarizes clinical features and management of children with SARS-CoV-2 infection and concludes that Bronchial thickening and ground-glass opacities were the main radiologic features in asymptomatic patients.

COVID-19 and Kawasaki Disease: Novel Virus and Novel Case.

This paper describes the case of a 6-month-old infant admitted and diagnosed with classic Kawasaki disease, who also screened positive for COVID-19 in the setting of fever and minimal respiratory symptoms, and the indications for CO VID-19 testing in the febrile infant.

SARS-CoV-2 infection in children

In order to prevent transmission of SARS-CoV-2, hygienic rules should be pursued in the community, social distancing should be observed, and the family members and contacts of patients who have been diagnosed should be screened and isolated.

Kawasaki Disease: Global Burden and Genetic Background

The global epidemiological patterns of KD are focused on, and several susceptibility genes were identified to be associated with the development of KD and increased risk of coronary artery lesions.

Do Cytokines Correlate with Refractory Kawasaki Disease in Children?

Immunogenetics of Kawasaki disease

Genetic aberrations in certain intracellular signaling pathways involving immune effector functions are found to be associated with increased susceptibility to Kawasaki disease and development of coronary artery abnormalities (CAAs).