Paclitaxel treatment reduces neointimal hyperplasia in cultured human saphenous veins.

@article{Schachner2007PaclitaxelTR,
  title={Paclitaxel treatment reduces neointimal hyperplasia in cultured human saphenous veins.},
  author={Thomas Schachner and Christina Maria Steger and Simone Heiss and Nikolaos E Bonaros and William Sterlacci and Guenther Laufer and Johannes O. Bonatti},
  journal={European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery},
  year={2007},
  volume={32 6},
  pages={906-11}
}
BACKGROUND Paclitaxel exerts antiproliferative properties by stabilizing microtubuli of the cell. The substance is in clinical use for drug-eluting coronary stents. We aimed to test the hypothesis that paclitaxel treatment can reduce neointimal hyperplasia in cultured human saphenous veins and thus might be useful for local pharmacologic treatment of vein grafts prior to coronary artery bypass grafting (CABG). METHODS The remnants of saphenous veins from 13 patients undergoing CABG were… CONTINUE READING