Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants

@article{Vclavkov2003PaclitaxelMI,
  title={Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants},
  author={Radka V{\'a}clav{\'i}kov{\'a} and Stanislav Horsk{\'y} and Petr Simek and I. T. Gut},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2003},
  volume={368},
  pages={200-209}
}
Paclitaxel is an important, recently introduced anti-neoplastic drug. Paclitaxel metabolites are virtually inactive in comparison with the parent drug. The study investigated whether phenolic antioxidants could inhibit metabolic inactivation sufficiently to increase paclitaxel effects. Cytochrome P450 (CYP)-catalysed metabolism of paclitaxel was investigated in rat and human liver microsomes. In rat microsomes, paclitaxel was metabolised mainly to C3'-hydroxypaclitaxel (C3'-OHP), less to C2… CONTINUE READING
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[ Food phenolics as protective compounds against atherosclerosis ] ( in Czech )

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