Paclitaxel-loaded poly(gamma-glutamic acid)-poly(lactide) nanoparticles as a targeted drug delivery system for the treatment of liver cancer.

@article{Liang2006PaclitaxelloadedPA,
  title={Paclitaxel-loaded poly(gamma-glutamic acid)-poly(lactide) nanoparticles as a targeted drug delivery system for the treatment of liver cancer.},
  author={H Liang and Chiung-Tong Chen and S Chen and Anandrao R. Kulkarni and Ya-Ling Chiu and Mei-Chin Chen and H. -I. Sung},
  journal={Biomaterials},
  year={2006},
  volume={27 9},
  pages={2051-9}
}
The study was to develop paclitaxel-loaded formulations using a novel type of self-assembled nanoparticles (P/NPs) composed of block copolymers synthesized by poly(gamma-glutamic acid) and poly(lactide). For the potential of targeting liver cancer cells, galactosamine was conjugated on the prepared nanoparticles (Gal-P/NPs). In the in vitro studies, it was found that both the P/NPs and the Gal-P/NPs had a similar release profile of paclitaxel. The activity in inhibiting the growth of HepG2… CONTINUE READING