Paclitaxel-loaded expansile nanoparticles in a multimodal treatment model of malignant mesothelioma.

BACKGROUND Malignant mesothelioma has a poor prognosis even when treated aggressively with multimodal therapy. Traditional murine tumor models can be used to evaluate drug efficacy and toxicity in malignant mesothelioma, but not to assess the effect of a multimodal approach that includes the surgical resection of tumor. We therefore developed a murine model… CONTINUE READING