Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis1

Abstract

The 70 kDa ribosomal S6 kinase (p70S6K) is important for cell growth and survival. Activation of p70S6K requires sequential phosphorylation of multiple serine and threonine sites often triggered by growth factors and hormones. Here, we report that paclitaxel, a microtubule-damaging agent, induces phosphorylation of p70S6K at threonine 421 and serine 424… (More)
DOI: 10.1038/sj.onc.1206175

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@article{Le2003PaclitaxelII, title={Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis1}, author={X. T. Le and Walter N. Hittelman and Jiaxin Liu and Amanda McWatters and Chun Li and Gordon B. Mills and Robert C. Bast}, journal={Oncogene}, year={2003}, volume={22}, pages={484-497} }