Paclitaxel-induced apoptosis in osteosarcoma cell line U-2 OS.

  title={Paclitaxel-induced apoptosis in osteosarcoma cell line U-2 OS.},
  author={Wei Guo and Chun Zeng and Fengquan Dong and Wei Lei},
  journal={Chinese medical journal},
  volume={115 12},
OBJECTIVE To observe the in vitro growth inhibitory and apoptosis-inducing effects of paclitaxel on the human osteosarcoma cell line U-2 OS. METHODS U-2 OS cells were treated with various concentrations of paclitaxel. Proliferation was determined by cell count in a neubauer cytometer chamber. Viability was assessed by trypan blue dye exclusion. Paclitaxel-induced morphologic alterations were visualized using light and transmission electron microscopy. The extent of paclitaxel-induced… CONTINUE READING
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