Paclitaxel-functionalized gold nanoparticles.

@article{Gibson2007PaclitaxelfunctionalizedGN,
  title={Paclitaxel-functionalized gold nanoparticles.},
  author={J. Gibson and Bishnu P Khanal and E. Zubarev},
  journal={Journal of the American Chemical Society},
  year={2007},
  volume={129 37},
  pages={
          11653-61
        }
}
  • J. Gibson, Bishnu P Khanal, E. Zubarev
  • Published 2007
  • Chemistry, Medicine
  • Journal of the American Chemical Society
  • Here we describe the first example of 2 nm gold nanoparticles (Au NPs) covalently functionalized with a chemotherapeutic drug, paclitaxel. The synthetic strategy involves the attachment of a flexible hexaethylene glycol linker at the C-7 position of paclitaxel followed by coupling of the resulting linear analogue to phenol-terminated gold nanocrystals. The reaction proceeds under mild esterification conditions and yields the product with a high molecular weight, while exhibiting an extremely… CONTINUE READING
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    E-mail: zubarev@rice
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    MSEC ) 7000; PDI ) 1.05. Acknowledgment. The authors gratefully acknowledge the financial support provided by the National Science Foundation (DMR-0547399 and CBET-0506832) and
    • MSEC ) 7000; PDI ) 1.05. Acknowledgment. The authors gratefully acknowledge the financial support provided by the National Science Foundation (DMR-0547399 and CBET-0506832) and