• DOI:10.1021/JA075181K
Corpus ID: 12034022

Paclitaxel-functionalized gold nanoparticles.

@article{Gibson2007PaclitaxelfunctionalizedGN,
  title={Paclitaxel-functionalized gold nanoparticles.},
  author={J. Gibson and Bishnu P Khanal and E. Zubarev},
  journal={Journal of the American Chemical Society},
  year={2007},
  volume={129 37},
  pages={
          11653-61
        }
}

J. Gibson, Bishnu P Khanal, E. Zubarev

Published 2007

Chemistry, Medicine

Journal of the American Chemical Society

Here we describe the first example of 2 nm gold nanoparticles (Au NPs) covalently functionalized with a chemotherapeutic drug, paclitaxel. The synthetic strategy involves the attachment of a flexible hexaethylene glycol linker at the C-7 position of paclitaxel followed by coupling of the resulting linear analogue to phenol-terminated gold nanocrystals. The reaction proceeds under mild esterification conditions and yields the product with a high molecular weight, while exhibiting an extremely… CONTINUE READING

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