Paclitaxel-dependent mutants have severely reduced microtubule assembly and reduced tubulin synthesis.

@article{Barlow2002PaclitaxeldependentMH,
  title={Paclitaxel-dependent mutants have severely reduced microtubule assembly and reduced tubulin synthesis.},
  author={Steven B. Barlow and M L Gonzalez-Garay and Fernando Cabral},
  journal={Journal of cell science},
  year={2002},
  volume={115 Pt 17},
  pages={3469-78}
}
A subset of mutant cell lines selected for resistance to the antitumor drug paclitaxel are unable to progress normally through mitosis unless the drug is present in the growth medium. Without paclitaxel the cells form defective spindles, undergo aberrant mitoses, fail to complete cell division and eventually die. Analysis of these drug-dependent cells revealed a low amount of microtubule polymer and less tubulin production than wild-type cells. Ribonuclease protection experiments indicated that… CONTINUE READING

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