Paclitaxel Induces Apoptosis in Breast Cancer Cells through Different Calcium—Regulating Mechanisms Depending on External Calcium Conditions

@inproceedings{Pan2014PaclitaxelIA,
  title={Paclitaxel Induces Apoptosis in Breast Cancer Cells through Different Calcium—Regulating Mechanisms Depending on External Calcium Conditions},
  author={Zhi song Pan and Andrew Avila and Lauren Gollahon},
  booktitle={International journal of molecular sciences},
  year={2014}
}
Previously, we reported that endoplasmic reticulum calcium stores were a direct target for paclitaxel initiation of apoptosis. Furthermore, the actions of paclitaxel attenuated Bcl-2 resistance to apoptosis through endoplasmic reticulum-mediated calcium release. To better understand the calcium-regulated mechanisms of paclitaxel-induced apoptosis in breast cancer cells, we investigated the role of extracellular calcium, specifically; whether influx of extracellular calcium contributed to and/or… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 73 references

Taxol (Paclitaxel) Injection Product Information

  • Squibb, B.-M
  • Available online: http://packageinserts.bms.com…
  • 2011
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