Paclitaxel (Taxol): a novel anticancer chemotherapeutic drug.

@article{Long1994PaclitaxelA,
  title={Paclitaxel (Taxol): a novel anticancer chemotherapeutic drug.},
  author={Harry J. Long},
  journal={Mayo Clinic proceedings},
  year={1994},
  volume={69 4},
  pages={341-5}
}
OBJECTIVE To review the literature on the clinical activity and toxic effects of paclitaxel (Taxol). DESIGN Results of phase I and II trials of Taxol in patients with various types of tumors are provided. MATERIAL AND METHODS Taxol is the first drug in a new class of antineoplastic agents known as the taxanes. These drugs demonstrate a novel mechanism of action characterized by promotion of the assembly of microtubules and stabilization of the tubules against depolymerization, resulting in… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

The role of chemotherapy in the treatment of malignant astrocytomas.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques • 2006

Taxanes propagate apoptosis via two cell populations with distinctive cytological and molecular traits.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research • 1998

Similar Papers

Loading similar papers…