Paclitaxel (Taxol): a novel anticancer chemotherapeutic drug.

  title={Paclitaxel (Taxol): a novel anticancer chemotherapeutic drug.},
  author={Harry J. Long},
  journal={Mayo Clinic proceedings},
  volume={69 4},
OBJECTIVE To review the literature on the clinical activity and toxic effects of paclitaxel (Taxol). DESIGN Results of phase I and II trials of Taxol in patients with various types of tumors are provided. MATERIAL AND METHODS Taxol is the first drug in a new class of antineoplastic agents known as the taxanes. These drugs demonstrate a novel mechanism of action characterized by promotion of the assembly of microtubules and stabilization of the tubules against depolymerization, resulting in… CONTINUE READING


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