Packing of coat protein amphipathic and transmembrane helices in filamentous bacteriophage M13: role of small residues in protein oligomerization.

@article{Williams1995PackingOC,
  title={Packing of coat protein amphipathic and transmembrane helices in filamentous bacteriophage M13: role of small residues in protein oligomerization.},
  author={Karen A. Williams and Mira Glibowicka and Zhongqiao Li and Hongye Li and Amir R. Khan and Y M Chen and Jiyi Wang and Donald A. Marvin and Charles M. Deber},
  journal={Journal of molecular biology},
  year={1995},
  volume={252 1},
  pages={6-14}
}
Filamentous bacteriophage M13, an important cloning and phage display vector, is encapsulated by ca 2700 copies of its 50-residue major coat protein (gene 8). This protein occurs as a membrane protein while stably inserted into its E. coli host inner membrane, and as a coat protein upon assembly and packing onto phage DNA in the lipid-free virion. To examine the specific protein-protein interactions underlying these processes, we used a combination of randomized and saturation mutagenesis of… CONTINUE READING

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