Packaging motor from double-stranded RNA bacteriophage phi12 acts as an obligatory passive conduit during transcription.

@article{Kainov2004PackagingMF,
  title={Packaging motor from double-stranded RNA bacteriophage phi12 acts as an obligatory passive conduit during transcription.},
  author={Denis E Kainov and J{\'i}ri L{\'i}sal and Dennis Henry Bamford and Roman Tuma},
  journal={Nucleic acids research},
  year={2004},
  volume={32 12},
  pages={3515-21}
}
Double-stranded RNA viruses sequester their genomes within a protein shell, called the polymerase complex. Translocation of ssRNA into (packaging) and out (transcription) of the polymerase complex are essential steps in the life cycle of the dsRNA bacteriophages of the Cystoviridae family (phi6-phi14). Both processes require a viral molecular motor P4, an NTPase, which bears structural and functional similarities to hexameric helicases. In effect, switching between the packaging and the… CONTINUE READING

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