Pacing-induced dys-synchrony preconditions rabbit myocardium against ischemia/reperfusion injury.

@article{Vanagt2006PacinginducedDP,
  title={Pacing-induced dys-synchrony preconditions rabbit myocardium against ischemia/reperfusion injury.},
  author={Ward Y R Vanagt and Richard N M Cornelussen and Quincy P Poulina and E. M. Blaauw and Kevin Vernooy and Jack P. M. Cleutjens and M W T van Bilsen and Tammo Delhaas and Frits W. Prinzen},
  journal={Circulation},
  year={2006},
  volume={114 1 Suppl},
  pages={I264-9}
}
BACKGROUND Because increased mechanical load induces preconditioning (PC) and dys-synchrony increases loading in late-activated regions, we investigated whether dys-synchrony induced by ventricular pacing (VP) at normal heart rate leads to cardioprotection. METHODS AND RESULTS Isolated working rabbit hearts were subjected to 35 minutes of global ischemia and 2 hours of reperfusion. Seven hearts underwent VP PC (3 periods of 5 minutes VP at the posterior left ventricular [LV] wall), 7 hearts… CONTINUE READING
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Stretch-induced protection shares a common Figure 7. Change in end-diastolic segment length (EDSL) in the anterior segment in the 3 groups before index ischemia

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