Pacing-induced dys-synchrony preconditions rabbit myocardium against ischemia/reperfusion injury.

  title={Pacing-induced dys-synchrony preconditions rabbit myocardium against ischemia/reperfusion injury.},
  author={Ward Y R Vanagt and Richard N M Cornelussen and Quincy P Poulina and E. M. Blaauw and Kevin Vernooy and Jack P. M. Cleutjens and M W T van Bilsen and Tammo Delhaas and Frits W. Prinzen},
  volume={114 1 Suppl},
BACKGROUND Because increased mechanical load induces preconditioning (PC) and dys-synchrony increases loading in late-activated regions, we investigated whether dys-synchrony induced by ventricular pacing (VP) at normal heart rate leads to cardioprotection. METHODS AND RESULTS Isolated working rabbit hearts were subjected to 35 minutes of global ischemia and 2 hours of reperfusion. Seven hearts underwent VP PC (3 periods of 5 minutes VP at the posterior left ventricular [LV] wall), 7 hearts… CONTINUE READING
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