Pacing for neurally mediated syncope: is placebo powerless?

  title={Pacing for neurally mediated syncope: is placebo powerless?},
  author={Michele Brignole and Richard Sutton},
  journal={Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology},
  volume={9 1},
BACKGROUND After two recent controlled trials failed to prove superiority of cardiac pacing over placebo in patients affected by neurally mediated syncope, a widely accepted opinion is that cardiac pacing therapy is not very effective and that a strong placebo effect exists. AIM To measure the effect of placebo pacing therapy. METHOD AND RESULTS We compared the recurrence rate of syncope during placebo vs. no treatment in controlled trials of drug or pacing therapy. Syncope recurred in 38… CONTINUE READING