Pacific Populations, Metabolic Disease and 'Just-So Stories': A Critique of the 'Thrifty Genotype' Hypothesis in Oceania.

@article{Gosling2015PacificPM,
  title={Pacific Populations, Metabolic Disease and 'Just-So Stories': A Critique of the 'Thrifty Genotype' Hypothesis in Oceania.},
  author={Anna L. Gosling and Hallie R. Buckley and Elizabeth A. Matisoo-Smith and Tony Raymond Merriman},
  journal={Annals of human genetics},
  year={2015},
  volume={79 6},
  pages={470-80}
}
Pacific populations have long been observed to suffer a high burden of metabolic disease, including obesity, type 2 diabetes and gout. The 'Thrifty Genotype' hypothesis has frequently been used to explain this high prevalence of disease. Here, the 'Thrifty Genotype' hypothesis and the evolutionary background of Pacific populations are examined. We question its relevance not only in the Pacific region but more generally. Not only has the hypothesis not been explicitly tested, but most… CONTINUE READING
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